A Novel Method for Measuring IgG-Dependent Triggering of Host FcyRs CD16, CD32 and CD64 Reveals a Selective Inhibition through Herpesviral FcyRs
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Localization of IgG Antigenic Sites in Goat Testicular Tissue
Article history: Received on: 14/12/2014 Revised on: 08/01/2015 Accepted on: 22/01/2015 Available online: 27/02/2015 Testis is the tissue with immune privilege which is maintained by blood-testis barrier to protect autoimmunogenic components of testis. IgG have binding affinity for CD16, CD32 and CD64 receptors present on various immune cells. Present study was conducted to investigate the IgG ...
متن کاملIGG and complement receptor expression on peripheral white blood cells in uraemic children.
BACKGROUND Phagocytosis of IgG- or complement-opsonized bacteria and antibody production by lymphocytes are regulated by cell surface receptors for IgG (FcgammaRI, FcgammaRII and FcgammaRIII) and complement (CR1 and CR3). We measured the effect of uraemia and dialysis treatment on FcgammaR and CR expression on leukocytes in blood. METHODS Blood samples were obtained from children: 40 treated ...
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Three different classes of Fc receptors for IgG (Fc gamma R) are currently distinguished in humans, of which polymorphonuclear phagocytes (PMN) normally express both low-affinity receptor classes--Fc gamma RII (CD32) and Fc gamma RIII (CD16). During therapy with granulocyte colony-stimulating factor (G-CSF), neutrophils from patients with various malignancies and different hematologic disorders...
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INTRODUCTION The high-affinity receptor for IgG Fcgamma/CD64 is critical for the development of lupus nephritis (LN). Cross-linking Fc receptor on recruited monocytes by IgG-containing immune complexes is a key step in immune-complex-mediated nephritis in systemic lupus erythematosus (SLE). The goal of this study was to determine whether expression of Fc receptor (FcgammaR) I on circulating mon...
متن کاملHeterogeneous expression of CD32 and CD32-mediated growth suppression in human myeloma cells.
BACKGROUND AND OBJECTIVES An increased level of serum M-protein IgG may affect the growth or survival of myeloma cells through the Fcgamma inverted exclamation mark receptor (FcgammaR) in human myelomas. We examined the expression of FcgammaR (CD32, CD16 and CD64) and compared the effect of anti-CD32 antibody on the viability of myeloma cells to that on the viability of normal plasma cells. D...
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